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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 734588Generated: October 27, 2026

Sodium triacetoxyborohydride → 5-{4-[2-(5-Bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinoline

https://huagongshe.com/reaction/734588

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium triacetoxyborohydrideHCID 5049666—
Reactant2-Methyl-5-piperazin-1-yl-quinolineHCID 49851901—
Reactant2-(5-Bromo-2-fluorophenyl)acetaldehydeHCID 57444351—
Product5-{4-[2-(5-Bromo-2-fluorophenyl)ethyl]-1-piperazinyl}-2-methylquinolineHCID 5744435095%

Reaction Steps

The title compound was prepared in 95% yield from (5-bromo-2-fluorophenyl)acetaldehyde (0.98 g), 2-methyl-5-(1-piperazinyl)quinoline (0.51 g) and sodium triacetoxyborohydride (0.95 g) according to the procedure described for Example 131.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07592346B2
Source datasetuspto-grants-2009_09
ORD IDord-08bfc6834c6448aa90a6104a438de702
Source noteuspto-grants-2009_09