HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → 1-(1-Methylethyl)-3-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | GSK163090 (dihydrochloride) | HCID 49836021 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-(1-Methylethyl)-3-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone dihydrochloride | HCID 68426625 | — |
Reaction Steps
The title compound was prepared according to the procedure described for Example 156 using 1-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-2-imidazolidinone (Example 85, 50 mg), DMF (1 mL), sodium hydride (60%, 10 mg) and 2-iodopropane (13 μL). Yield 17 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592346B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-ebe43de5fe8f45a2a1cb4753d2fbcc69 |
| Source note | uspto-grants-2009_09 |