Formic Acid → HCID 86621475, compound

Participants

Reaction Steps

A solution of 2 cm3 (52.9 mmol) of formic acid in 5 cm3 (52.9 mmol) of acetic anhydride is added, at a temperature close to 25° C., to a solution of 0.3 g (1.21 mmol) of 2-amino-4-(4-nitrophenyl)-1H-pyrrole-3-carboxamide in 5 cm3 of absolute ethanol. After stirring for 2 hours at this temperature, the reaction medium is poured into 100 cm3 of water. The suspension is then filtered. The solid is drained, dried to give 0.257 g of 2-formylamino-4-(4-nitrophenyl)-1H-pyrrole-3-carboxamide in the form of a green powder. 1H NMR (400 MHz, (CD3)2SO, —δ in ppm), from 6.22 to 8.53 (very broad m, 2H); 6.78 (d, J=3.0 Hz, 1H); 7.64 (d, J=9.0 Hz, 2H); 8.19 (d, J=9.0 Hz, 2H); 8.32 (d, J=1.5 Hz, 1H); 10.55 (broad s, 1H); 11.6 (broad s, 1H).

Provenance & Evidence