HCID 69060826, compound → HCID 69057492, compound

Participants

Reaction Steps

0.195 g (0.61 mmol) of 2-butyrylamino-4-(4-nitrophenyl)-1H-pyrrole-3-carboxamide is added at a temperature in the region of 25° C. to a suspension of 0.068 g (0.064 mmol) of 10% palladium on carbon in 20 cm3 of methanol. After hydrogenating for 5 hours in an autoclave under 2 bar of hydrogen, at a temperature in the region of 25° C., the reaction mixture is filtered, the catalyst is rinsed with twice 10 cm3 of methanol and then the filtrate is concentrated to dryness under reduced pressure (2.7 kPa) to give 0.207 g of 2-butyrylamino-4-(4-aminophenyl)-1H-pyrrole-3-carboxamide, in the form of a cream solid. 1H NMR (400 MHz, (CD3)2SO, —δ in ppm) 0.94 (t, J=7.5 Hz, 3H); 1.63 (m, 2H); 2.37 (t, J=7.5 Hz, 2H); 5.11 (broad s, 2H); from 6.05 to 8.45 (very broad m, 2H); 6.24 (d, J=2.5 Hz, 1H); 6.60 (d, J=8.5 Hz, 2H); 6.99 (d, J=8.5 Hz, 2H); 10.8 (broad s, 1H); 11.3 (broad s, 1H).

Provenance & Evidence