HCID 69055710, compound → HCID 69059862, compound

Participants

Reaction Steps

0.115 g (0.362 mmol) of 4-(4-nitrophenyl)-2-(3-ethylureido)-1H-pyrrole-3-carboxamide is added at a temperature in the region of 25° C. to a suspension of 0.067 g (0.0636 mmol) of 10% palladium on carbon in 15 cm3 of methanol. After hydrogenating for 2.5 hours in an autoclave under 2 bar of hydrogen, at a temperature in the region of 25° C., the reaction mixture is filtered, the catalyst is rinsed with three times 5 cm3 of methanol and then the filtrate is concentrated to dryness under reduced pressure (2.7 kPa) to give 0.056 g of 4-(4-aminophenyl)-2-(3-ethylureido)-1H-pyrrole-3-carboxamide, in the form of an orange solid; ES+: m/z=289 (MH+).

Provenance & Evidence