HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 68828054, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Dimethyl Sulfate | HCID 6497 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-(4-Chloro-2-fluorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydro-3-pyridinecarboxylic acid | HCID 68826057 | — |
| Product | HCID 68828054 | HCID 68828054 | 73% |
Reaction Steps
The product of Example 3 Step 2 (3.0 g, 10.08 mmol, 1.0 equiv) was dissolved in 100 mL DMF and NaH (806 mg, 20.15 mmol, 2.0 equiv) was added slowly to the reaction mixture. Me2SO4 (1.9 mL, 20.15 mmol, 2.0 equiv) was added and the reaction was stirred at room temperature for 45 min. The reaction was quenched with water and filtered. The precipitate was washed with water and air dried to provide 2.29 g (73%) of the title compound as a light yellow solid. MS (ES+) m/e 312 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592357B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-ae974346bc6d4314bbd9c22ce01d6380 |
| Source note | uspto-grants-2009_09 |