HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 4-chloro-3-sulfamoylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Chloro-3-sulfamoylbenzoic acid | HCID 14568 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Methyl 4-chloro-3-sulfamoylbenzoate | HCID 4277179 | 95% |
Reaction Steps
3-(Aminosulfonyl)-4-chlorobenzoic acid (943 mg, 4.0 mmol) was heated at 70° C. in CH3OH (10 mL) with 3 drops of concentrated sulfuric acid for 34 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (950 mg, 95%) as a white solid. MS (ES+) m/z 250 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592357B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-2ba078ff6fe9468996bc53adcbb229cd |
| Source note | uspto-grants-2009_09 |