HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Benzoic acid, 3-(aminosulfonyl)-, methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 3-Sulfamoylbenzoic acid | HCID 229352 | — |
| Catalyst | Sulfuric Acid | HCID 1118 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | Benzoic acid, 3-(aminosulfonyl)-, methyl ester | HCID 108836 | 98% |
Reaction Steps
3-(Aminosulfonyl)benzoic acid (603 mg, 3.0 mmol) was heated at 80° C. in CH3OH (3 mL) with 3 drops of concentrated sulfuric acid for 60 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (630 mg, 98%) as a white solid. MS (ES+) m/z 216 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592357B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-a4b72a81d93e43e8aa724688c2f86acf |
| Source note | uspto-grants-2009_09 |