HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Benzyl-4-(trifluoromethyl)piperidin-4-ol → 4-(Trifluoromethyl)-4-piperidinol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Benzyl-4-(trifluoromethyl)piperidin-4-ol | HCID 23003702 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(Trifluoromethyl)-4-piperidinol | HCID 17951321 | — |
Reaction Steps
A suspension of 6.48 g (25.00 mmol) of 1-benzyl-4-trifluoromethylpiperidin-4-ol and 810 mg Pd/C (10%) in 100 mL of MeOH was hydrogenated at RT and 3 bar hydrogen pressure for 17 hours. The catalyst was filtered off and the filtrate evaporated down in vacuo. Yield: 4.22 g (quant. yield); C6H10F3NO (M=169.145); calc.: molpeak (M+H)+: 170; found: molpeak (M+H)+: 17; Rf value: 0.00 (silica gel, cyc/EtOAc 2:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-ab68702b99324b55b38f6f38ef6bd6e7 |
| Source note | uspto-grants-2009_09 |