Potassium Carbonate → HCID 69063371, compound

Participants

Reaction Steps

A mixture of 1.00 g (83.15 mmol) of benzyl 4-(2,2,2-trifluoro-1-hydroxyethyl)piperidine-1-carboxylate and 4.95 g (11.66 mmol) Dess-Martin periodinane in 30 mL of DCM was stirred for 20 hours at RT and then made alkaline with saturated aqueous potassium carbonate solution. The reaction mixture was filtered and the phases of the filtrate were separated. The organic phase was dried over sodium sulfate and evaporated down in vacuo. Yield: 896 mg (90% of theoretical); C15H16F3NO3 (M=315.288); calc.: molpeak (M−H)−: 314; found: molpeak (M−H)−: 314; Rf value: 0.39 (silica gel, cyc/EtOAc 2: 1).

Provenance & Evidence