反应详情

43.80 g of AD-Mix-Beta was placed in 3000 mL of tert-butanol/water (1:1) and stirred for 20 minutes at RT. The mixture was cooled to 0° C., 2.97 g (31.25 mmol) of methanesulfonamide and 7.54 g (31.25 mmol) of 1-benzyl-4-trifluoromethyl-1,2,3,6-tetrahydropyridine were added, the cooling bath was removed, and the mixture was stirred for 8 days at RT. Another 22 g of AD-Mix-Beta and 1.5 g of methanesulfonamide were added and the mixture was again stirred for 7 days at RT. 11.2 g of sodium sulfite was added and the mixture was stirred for 1 hour. 200 mL of semisaturated aqueous sodium bicarbonate solution was added and the aqueous phase was exhaustively extracted with DCM. The combined organic phases were dried over sodium sulfate and evaporated down in vacuo. The crude product was purified by MPLC-MS (Grom-Sil 120 ODS 4, 10 μm, gradient 0.15% formic acid in water/acetonitrile 90:10→10:90 in 10 minutes). The eluates were combined, evaporated down in vacuo, and neutralized with 100 mL of semisaturated aqueous sodium bicarbonate solution. The aqueous phase was extracted with EtOAc, and the combined organic phases were dried over sodium sulfate and evaporated down in vacuo. Yield: 1.51 g (17% of theoretical); C13H16F3NO2 (M=275.267); calc.: molpeak (M+H)+: 276; found: molpeak (M+H)+: 276; Rf value: 0.40 (silica gel, cyc/EtOAc 2:1).

1. temperatureThe mixture was cooled to 0° C.
2. customthe cooling bath was removed
3. stirringthe mixture was stirred for 8 days at RT
4. additionAnother 22 g of AD-Mix-Beta and 1.5 g of methanesulfonamide were added
5. stirringthe mixture was again stirred for 7 days at RT
6. addition11.2 g of sodium sulfite was added
7. stirringthe mixture was stirred for 1 hour
8. addition200 mL of semisaturated aqueous sodium bicarbonate solution was added
9. extractionthe aqueous phase was exhaustively extracted with DCM
10. dry with materialThe combined organic phases were dried over sodium sulfate
11. customevaporated down in vacuo
12. customThe crude product was purified by MPLC-MS (Grom-Sil 120 ODS 4, 10 μm, gradient 0.15% formic acid in water/acetonitrile 90:10→10:90 in 10 minutes)
13. customevaporated down in vacuo
14. extractionThe aqueous phase was extracted with EtOAc
15. dry with materialthe combined organic phases were dried over sodium sulfate
16. customevaporated down in vacuo