HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl acetate methanol ammonia → (S)-1-pyrrolidin-2-ylcyclopropanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl acetate methanol ammonia | HCID 21873639 | — |
| Reactant | 1-((S)-1-benzylpyrrolidin-2-yl)cyclopropanol | HCID 69058142 | — |
| Product | (S)-1-pyrrolidin-2-ylcyclopropanol | HCID 11147720 | — |
Reaction Steps
The product was obtained analogously to IP 5d starting from 745 mg (3.43 mmol) 1-((S)-1-benzylpyrrolidin-2-yl)cyclopropanol. Yield: 350 mg (80% of theoretical); C7H13NO (M=127.184); calc.: molpeak (M+H)+: 128; found: molpeak (M+H)+: 128; Rf value: 0.10 (silica gel, EtOAc/MeOH/NH3 5:5:0.5).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-b268215058044d569af2e895185547fa |
| Source note | uspto-grants-2009_09 |