HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 1-[2-(4-Iodophenoxy)ethyl]-4-methylpiperidin-4-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Methylpiperidin-4-ol | HCID 15649174 | — |
| Reactant | 2-(4-Iodophenoxy)ethyl methanesulfonate | HCID 86601131 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-[2-(4-Iodophenoxy)ethyl]-4-methylpiperidin-4-ol | HCID 57845327 | — |
Reaction Steps
The product was obtained analogously to Example 1.1g (3 hours at 70° C., potassium carbonate as base) from 4.79 g (14.0 mmol) of 2-(4-iodophenoxy)ethyl methanesulfonate and 1.94 g (16.8 mmol) of 4-methylpiperidin-4-ol. Yield: 3.40 g (67% of theoretical); C14H20INO2 (M=361.219); calc.: molpeak (M+H)+: 362; found: molpeak (M+H)+: 362; Rf value: 0.20 (silica gel, DCM/MeOH 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-c40b3c1d88554906aaba90ebb0f7e914 |
| Source note | uspto-grants-2009_09 |