HuagongsheHuagongshe Chemistry Print Report · For research reference only
BROMINE CHLORIDE (BrCl) → 2-{2-Bromo-4-[5-(4-chlorophenyl)-3-fluoropyridin-2-ylethynyl]phenoxy}ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | BROMINE CHLORIDE (BrCl) | HCID 61697 | — |
| Reactant | 5-(4-Chlorophenyl)-2-ethynyl-3-fluoropyridine | HCID 60055416 | — |
| Reactant | 2-(2-Bromo-4-iodophenoxy)ethanol | HCID 69062443 | — |
| Product | 2-{2-Bromo-4-[5-(4-chlorophenyl)-3-fluoropyridin-2-ylethynyl]phenoxy}ethanol | HCID 69064880 | — |
Reaction Steps
The product was prepared analogously to Example 7.1e starting from 2-(2-bromo-4-iodophenoxy)ethanol and 5-(4-chlorophenyl)-2-ethynyl-3-fluoropyridine. Yield: 1.60 g (82% of theoretical); C21H14BrClFNO2 (M=446.697); calc.: molpeak (M+H)+: 446/448/450 (BrCl); found: molpeak (M+H)+: 446/448/450 (BrCl); HPLC-MS: 6.38 minutes (method B).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-f24aba2a1790406dbb8c819b2ab39e14 |
| Source note | uspto-grants-2009_09 |