5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 69060156, compound

HRID 734805Notes

Reaction equation

HRID 734805 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:11][CH2:12][OH:13])[N:6]=[CH:5]2.[Cl:14][C:15]1[CH:20]=[CH:19][C:18]([C:21]2[CH:22]=[CH:23][C:24]([C:27]#[CH:28])=[N:25][CH:26]=2)=[CH:17][CH:16]=1>>[Cl:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]2[CH:22]=[CH:23][C:24]([C:27]#[C:28][C:2]3[CH:3]=[C:4]4[C:8](=[CH:9][CH:10]=3)[N:7]([CH2:11][CH2:12][OH:13])[N:6]=[CH:5]4)=[N:25][CH:26]=2)=[CH:19][CH:20]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69058800HCID 69058800, compound

Product 1

HCID 69060156HCID 69060156, compound

Procedure

The product was prepared analogously to Example 7.1e starting from 2-(5-iodoindazol-1-yl)ethanol and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 1.60 g (73% of theoretical); C22H16ClN3O (M=373.835); calc.: molpeak (M+H)+: 374/376 (Cl); found: molpeak (M+H)+: 374/376 (Cl).

Workup

  1. customThe product was prepared analogously to Example 7.1e

Sources & evidence

ORD record
ord-ec38037cccff4496a2a5cdee9c507394
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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