Potassium tert-butoxide → HCID 69060853, compound

HRID 734809Notes

Reaction equation

HRID 734809 reaction equation
[OH:1][CH2:2][CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([I:11])=[CH:7][C:6]=1[C:12](=O)[CH3:13].[CH3:15]C(C)([O-])C.[K+]>>[I:11][C:8]1[CH:9]=[CH:10][C:5]([O:4][CH2:3][CH2:2][OH:1])=[C:6]([C:12]([CH3:13])=[CH2:15])[CH:7]=1

Participants

3

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 69061244HCID 69061244, compound

Product 1

HCID 69060853HCID 69060853, compound

Procedure

The product was prepared analogously to Example 11.1b starting from 1-[2-(2-hydroxyethoxy)-5-iodophenyl]ethanone and using potassium tert-butoxide as base. Yield: 2.50 g (43% of theoretical); C11H13IO2 (M=304.124); calc.: molpeak (M+H)+: 305; found: molpeak (M+H)+: 305; HPLC-MS: 5.65 minutes (method B).

Workup

  1. customThe product was prepared analogously to Example 11.1b
  2. custom5.65 minutes (method B)

Sources & evidence

ORD record
ord-dd5db8f1dd754875acab926549c6bf11
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

Loading…