BROMINE CHLORIDE (BrCl) → 2-{4-[3-Bromo-5-(4-chlorophenyl)pyridin-2-ylethynyl]phenoxy}ethanol

HRID 734818Notes

Reaction equation

HRID 734818 reaction equation
[Br:1][C:2]1[C:3]([C:15]#[CH:16])=[N:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:7]=1.I[C:18]1[CH:27]=[CH:26][C:21]([O:22][CH2:23][CH2:24][OH:25])=[CH:20][CH:19]=1.BrCl>>[Br:1][C:2]1[C:3]([C:15]#[C:16][C:18]2[CH:27]=[CH:26][C:21]([O:22][CH2:23][CH2:24][OH:25])=[CH:20][CH:19]=2)=[N:4][CH:5]=[C:6]([C:8]2[CH:13]=[CH:12][C:11]([Cl:14])=[CH:10][CH:9]=2)[CH:7]=1

Participants

4

Reactant 3

HCID 61697BROMINE CHLORIDE (BrCl)2×HCID 35132082-(4-Iodophenoxy)ethanolHCID 86077051HCID 86077051, compound

Product 1

HCID 690586502-{4-[3-Bromo-5-(4-chlorophenyl)pyridin-2-ylethynyl]phenoxy}ethanol

Procedure

The product was prepared analogously to Example 7.1e starting from 3-bromo-5-(4-chlorophenyl)-2-ethynylpyridine and 2-(4-iodophenoxy)ethanol. Yield: 0.18 g (28% of theoretical); C21H15BrClNO2 (M=428.706); calc.: molpeak (M+H)+: 428/430/432 (BrCl); found: molpeak (M+H)+: 428/430/432 (BrCl).

Workup

  1. customThe product was prepared analogously to Example 7.1e

Sources & evidence

ORD record
ord-6f6408511ff741ada781877c68211bd1
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

Loading…