HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 64764382, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1,3-Bis(diphenylphosphino)propane | HCID 81219 | — |
| Reactant | HCID 69056351 | HCID 69056351 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Rhodium, di-mu-chlorobis((1,2,5,6-eta)-1,5-cyclooctadiene)di- | HCID 6436379 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 64764382 | HCID 64764382 | — |
Reaction Steps
A solution of 0.41 g (1.38 mmol) of 1-[2-(4-bromo-2-vinylphenoxy)ethyl]pyrrolidine and 0.41 mL (2.94 mmol) of triethylamine in 25 mL of MeOH was degassed with argon and then combined with 35.5 mg (0.072 mmol) of bis(1,5-cyclooctadiene)dirhodium (I) dichloride and 57.1 mg (0.138 mmol) of 1,3-bis(diphenylphosphino)propane. The mixture was hydrogenated at RT and 3 bar hydrogen pressure. The reaction mixture was evaporated down in vacuo, and the residue was stirred with EtOAc, filtered, and the filtrate was evaporated down in vacuo. Yield: 0.26 g (87% of theoretical); C14H21NO (M=219.330); calc.: molpeak (M+H)+: 220; found: molpeak (M+H)+: 220.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-60640f3e9478437e9c146041689b39d3 |
| Source note | uspto-grants-2009_09 |