5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 57845307, compound

HRID 734840Notes

Reaction equation

HRID 734840 reaction equation
I[C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[C:4]([CH2:16][CH3:17])[CH:3]=1.[Cl:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[CH:32])=[N:29][CH:30]=2)=[CH:21][CH:20]=1>>[Cl:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:26]=[CH:27][C:28]([C:31]#[C:32][C:2]3[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]4[CH2:13][CH2:12][CH2:11][CH2:10]4)=[C:4]([CH2:16][CH3:17])[CH:3]=3)=[N:29][CH:30]=2)=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69054049HCID 69054049, compound

Product 1

HCID 57845307HCID 57845307, compound

Procedure

The product was obtained analogously to Example 7.1e starting from 1-[2-(4-iodo-2-ethylphenoxy)ethyl]pyrrolidine and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 44 mg (12% of theoretical); C27H27ClN2O (M=430.969); calc.: molpeak (M+H)+: 431/433 (Cl); found: molpeak (M+H)+: 431/433 (Cl); HPLC-MS: 5.74 minutes (method A).

Workup

  1. customThe product was obtained analogously to Example 7.1e
  2. custom5.74 minutes (method A)

Sources & evidence

ORD record
ord-46cade47f62641de9f36cd4c5f0ee2ca
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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