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p-Formylphenylboric acid → 4-(6-{4-[2-(4-Methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridin-3-yl)benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | p-Formylphenylboric acid | HCID 21940015 | — |
| 反応物 | 5-Bromo-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridine | HCID 69060172 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 4-(6-{4-[2-(4-Methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridin-3-yl)benzaldehyde | HCID 57845295 | — |
反応手順
The product was obtained analogously to Example 1.1e starting from 5-bromo-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridine and 4-formylphenylboric acid. Yield: 0.20 g (47% of theoretical); C28H28N2O2 (M=424.534); calc.: molpeak (M+H)+425; found: molpeak (M+H)+: 425; Rf value: 0.40 (silica gel, DCM/MeOH 9:1).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592358B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-15ba0b71536643f1b117aabb498c32f7 |
| 出典メモ | uspto-grants-2009_09 |