5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 69054010, compound

HRID 734854Notes

Reaction equation

HRID 734854 reaction equation
I[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([CH2:12][OH:13])[CH:6]=[C:5]2[CH3:14].[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([C:22]2[CH:23]=[CH:24][C:25]([C:28]#[CH:29])=[N:26][CH:27]=2)=[CH:18][CH:17]=1>>[Cl:15][C:16]1[CH:17]=[CH:18][C:19]([C:22]2[CH:23]=[CH:24][C:25]([C:28]#[C:29][C:2]3[CH:3]=[C:4]4[C:9](=[CH:10][CH:11]=3)[N:8]=[C:7]([CH2:12][OH:13])[CH:6]=[C:5]4[CH3:14])=[N:26][CH:27]=2)=[CH:20][CH:21]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69059830HCID 69059830, compound

Product 1

HCID 69054010HCID 69054010, compound

Procedure

The product was obtained analogously to Example 7.1 e starting from (6-iodo-4-methylquinolin-2-yl)methanol and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 50 mg (19% of theoretical); C24H17ClN2O (M=384.857); calc.: molpeak (M+H)+: 385/387 (Cl); found: molpeak (M+H)+: 385/387 (Cl); HPLC-MS: 5.50 minutes (method B).

Workup

  1. customThe product was obtained analogously to Example 7.1 e
  2. custom5.50 minutes (method B)

Sources & evidence

ORD record
ord-2593b5a1cb04452b94a067d982b69723
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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