5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 57845323, compound

HRID 734860Notes

Reaction equation

HRID 734860 reaction equation
I[C:2]1[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]2[CH2:13][CH2:12][CH2:11][CH2:10]2)=[C:4]([O:16][CH:17]([CH3:19])[CH3:18])[CH:3]=1.[Cl:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[CH:34])=[N:31][CH:32]=2)=[CH:23][CH:22]=1>>[Cl:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[CH:28]=[CH:29][C:30]([C:33]#[C:34][C:2]3[CH:15]=[CH:14][C:5]([O:6][CH2:7][CH2:8][N:9]4[CH2:13][CH2:12][CH2:11][CH2:10]4)=[C:4]([O:16][CH:17]([CH3:19])[CH3:18])[CH:3]=3)=[N:31][CH:32]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 578453285-(4-Chloro-phenyl)-2-ethynyl-pyridineHCID 69055747HCID 69055747, compound

Product 1

HCID 57845323HCID 57845323, compound

Procedure

The product was obtained analogously to Example 7.1e starting from 1-[2-(4-iodo-2-isopropoxyphenoxy)ethyl]pyrrolidine and 5-(4-chlorophenyl)-2-ethynylpyridine. Yield: 7 mg (8% of theoretical); C28H29ClN2O2 (M=460.995); calc.: molpeak (M+H)+:461/463 (Cl); found: molpeak (M+H)+: 461/463 (Cl); HPLC-MS: 10.50 minutes (method A).

Workup

  1. customThe product was obtained analogously to Example 7.1e
  2. custom10.50 minutes (method A)

Sources & evidence

ORD record
ord-3185fccd29a146aa86669596b4253273
Source dataset
uspto-grants-2009_09
Patent number
US07592358B2

Reaction notes

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