5-(4-Chloro-phenyl)-2-ethynyl-pyridine → HCID 57845314, compound

Participants

Reaction Steps

The product was obtained analogously to Example 7.1e starting from (4-iodophenyl)-(S)-1-pyrrolidin-2-ylmethylamine and 5-(4-chlorophenyl)-2-ethynylpyridine. The crude product was purified by MPLC (Hyperprep HS C18, 8 μm, gradient 0.15% formic acid in water/acetonitrile 10/90→90/10 v/v). The eluates were evaporated down in vacuo and the residue was neutralized with sat. aqueous sodium bicarbonate solution. The aqueous phase was extracted with DCM, dried over magnesium sulfate and evaporated down in vacuo. Yield: 35 mg (11% of theoretical); C24H22ClN3 (M=387.904); calc.: molpeak (M+H)+:388/390 (Cl); found: molpeak (M+H)+:388/390 (Cl); HPLC-MS: 5.0 minutes (method B).

Provenance & Evidence