N-BOC-ethylenediamine → HCID 70810523, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 8.86 g (31.20 mmol) of 5-bromo-2-iodopyridine and 10.00 g (62.42 mmol) of tert-butyl (2-aminoethyl)carbamate was stirred for 3 hours at 170° C. The reaction mixture was cooled to RT and diluted with EtOAc. The organic phase was washed with saturated aqueous sodium bicarbonate solution, dried over magnesium sulfate, and evaporated down in vacuo. The crude product was purified by chromatography (silica gel, cyc/EtOAc 4:1). Yield: 2.37 g (24% of theoretical); C12H18BrN3O2 (M=316.194); calc.: molpeak (M+H)+:316/318 (Br); found: molpeak (M+H)+:316/318 (Br); Rf value: 0.22 (silica gel, cyc/EtOAc 2:1).

Provenance & Evidence