2-Amino-5-bromopyrazine → 5-(2,4-Dichlorophenyl)pyrazin-2-ylamine

Participants

Reaction Steps

The product was prepared analogously to Example 48.1a from 1.74 g (10.0 mmol) of 5-bromopyrazin-2-ylamine and 1.91 g (10.0 mmol) of 2,4-dichlorophenylboric acid. Yield: 800 mg (33% of theoretical); C10H7Cl2N3 (M=240.088); calc.: molpeak (M+H)+240/242/244 (2 Cl); found: molpeak (M+H)+:240/242/244 (2 Cl); Rf value: 0.35 (silica gel, PE/EtOAc 7:3).

Provenance & Evidence