1-[2-(4-Iodophenoxy)ethyl]-4-methylpiperidin-4-ol → 1-(2-{4-[5-(2,4-Dichlorophenyl)pyrazin-2-ylethynyl]phenoxy}ethyl)-4-methylpiperidin-4-ol

Participants

Reaction Steps

The product was prepared analogously to Example 48.1c from 180 mg (0.72 mmol) of 2-(2,4-dichlorophenyl)-5-ethynylpyrazine and 260 mg (0.72 mmol) of 1-[2-(4-iodophenoxy)ethyl]-4-methylpiperidin-4-ol (IP 15) (stirring the reaction mixture overnight at RT). Yield: 16 mg (5% of theoretical); C26H25Cl2N3O2 (M=482.401); calc.: molpeak (M+H)+482/484/486 (2 Cl); found: molpeak (M+H)+:482/484/486 (2 Cl); HPLC-MS: 7.5 minutes (method G).

Provenance & Evidence