HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethylsilylacetylene → 2-(4-Chloro-2-methylphenyl)-5-trimethylsilanylethynylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethylsilylacetylene | HCID 66111 | — |
| Reactant | 2-(4-Chloro-2-methylphenyl)-5-iodopyrazine | HCID 86076978 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(4-Chloro-2-methylphenyl)-5-trimethylsilanylethynylpyrazine | HCID 69063069 | — |
Reaction Steps
The product was prepared analogously to Example 48.1c from 1.70 g (5.14 mmol) of 2-(4-chloro-2-methylphenyl)-5-iodopyrazine and 0.80 mL (5.66 mmol) of trimethylsilylacetylene (using triethylamine as base). Yield: 700 mg (45% of theoretical); C16H17ClN2Si (M=300.858); calc.: molpeak (M+H)+:301/303 (Cl); found: molpeak (M+H)+:301/303 (Cl); Rf value: 0.5 (silica gel, PE/EtOAc 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-2a42b89c40474d81b60473bd42b4f197 |
| Source note | uspto-grants-2009_09 |