HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Chloro-2-methylphenyl)-5-trimethylsilanylethynylpyrazine → 2-(4-Chloro-2-methylphenyl)-5-ethynylpyrazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Chloro-2-methylphenyl)-5-trimethylsilanylethynylpyrazine | HCID 69063069 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-(4-Chloro-2-methylphenyl)-5-ethynylpyrazine | HCID 86076981 | — |
Reaction Steps
The product was prepared analogously to Example 1.1c from 700 mg (2.33 mmol) of 2-(4-chloro-2-methylphenyl)-5-trimethylsilanylethynylpyrazine (40 minutes at RT, DCM as solvent). Yield: 200 mg (38% of theoretical); C13H9ClN2 (M=228.677); calc.: molpeak (M+H)+:229/231 (Cl); found: molpeak (M+H)+:229/231 (Cl); Rf value: 0.2 (silica gel, PE/EtOAc 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-ced1ef60cc2c40f0ad842506ac69ad27 |
| Source note | uspto-grants-2009_09 |