HuagongsheHuagongshe Chemistry Print Report · For research reference only
(tert-Butyldimethylsilyl)acetylene → 5-Bromo-2-[(tert-butyldimethylsilanyl)ethynyl]-3-fluoropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (tert-Butyldimethylsilyl)acetylene | HCID 2757281 | — |
| Reactant | 2,5-Dibromo-3-fluoropyridine | HCID 22412832 | — |
| Product | 5-Bromo-2-[(tert-butyldimethylsilanyl)ethynyl]-3-fluoropyridine | HCID 69061006 | — |
Reaction Steps
The product was prepared analogously to Example 48.1c from 23.4 g (92.0 mmol) of 2,5-dibromo-3-fluoropyridine and 17.5 mL (92.0 mmol) of tert-butylethynyldimethylsilane (with triethylamine as base and PdCl2(PPh3)2 as catalyst). Yield: 23.3 g (81% of theoretical); C13H17BrFNSi (M=314.269); calc.: molpeak (M+H)+:314/316 (Br); found: molpeak (M+H)+:314/316 (Br).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-e2267c8d0bd34b59952a6f475fca47d8 |
| Source note | uspto-grants-2009_09 |