1-(2-(4-Iodophenoxy)ethyl)-4-methylpiperidine → 3-Fluoro-5-(4-methylcyclohex-1-enyl)-2-{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenylethynyl}pyridine

Participants

Reaction Steps

The product was prepared analogously to Example 48.1c from 130 mg (0.60 mmol) of 2-ethynyl-3-fluoro-5-(4-methylcyclohex-1-enyl)pyridine and 207 mg (0.60 mmol) of 1-[2-(4-iodophenoxy)ethyl]-4-methylpiperidine (Example 19.1 a) (24 at RT, triethylamine as base). Yield: 15 mg (6% of theoretical); C28H33FN2O (M=432.573); calc.: molpeak (M+H)+:433; found: molpeak (M+H)+:433; HPLC-MS: 5.60 minutes (method H).

Provenance & Evidence