HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(4-Iodophenyl)ethan-1-ol → 2-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]phenyl}ethanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(4-Iodophenyl)ethan-1-ol | HCID 3040770 | — |
| Reactant | 5-(4-Chloro-phenyl)-2-ethynyl-pyridine | HCID 57845328 | — |
| Product | 2-{4-[5-(4-Chlorophenyl)pyridin-2-ylethynyl]phenyl}ethanol | HCID 69057844 | — |
Reaction Steps
The product was prepared analogously to Example 48.1c from 1.74 g (8.06 mmol) of 5-(4-chlorophenyl)-2-ethynylpyridine and 2.00 g (8.06 mmol) of 2-(4-iodophenyl)ethanol (24 at RT, triethylamine as base and acetonitrile as solvent). Yield: 1.80 g (67% of theoretical); C21H16ClNO (M=333.811); calc.: molpeak (M+H)+:334/336 (Cl); found: molpeak (M+H)+:334/336 (Cl).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-e44bce97461e43f191b1396a4b858b0a |
| Source note | uspto-grants-2009_09 |