HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 69061534, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-(4-Chloro-phenyl)-2-ethynyl-pyridine | HCID 57845328 | — |
| Reactant | 4-Iodo-2-methylbenzeneethanol | HCID 69057793 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 69061534 | HCID 69061534 | — |
Reaction Steps
Under an argon atmosphere 16 mg (0.02 mmol) of PdCl2(dppf) and 4 mg (0.02 mmol) of CuI were added to a repeatedly degassed solution of 940 mg (1.79 mmol) of 2-(4-iodo-2-methylphenyl)ethanol, 383 mg (1.79 mmol) of 5-(4-chlorophenyl)-2-ethynylpyridine (IP 13), and 0.52 mL (3.77 mmol) of triethylamine in 8 mL of acetonitrile and the mixture was stirred overnight at RT. The precipitate was suction filtered and washed with acetonitrile. Yield: 270 mg (43% of theoretical); C22H18ClNO (M=347.837); calc.: molpeak (M+H)+:348/50 (Cl); found: molpeak (M+H)+:348/50 (Cl); HPLC-MS: 6.15 minutes (method H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592358B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-7bf90355ada644a18ff7f8a0653442a4 |
| Source note | uspto-grants-2009_09 |