4-Methylpiperidine → HCID 57845317, compound

Participants

Reaction Conditions

Reaction Steps

0.09 mL (0.77 mmol) of 4-methylpiperidine was added to a solution of 110 mg (0.26 mmol) of 2-{4-[5-(4-chlorophenyl)pyridin-2-ylethynyl]-2-methylphenyl}ethyl methanesulfonate in 2 mL of DMF and heated to 69° C. After the reaction had ended, the reaction solution was cooled and the precipitate formed was suction filtered. Yield: 40 mg (36% of theoretical); C28H29ClN2 (M=428.996) C28H29ClN2; calc.: molpeak (M+H)+:429/431 (Cl); found: molpeak (M+H)+:429/431 (Cl); HPLC-MS: 5.96 minutes (method G).

Provenance & Evidence