HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propiolic Acid → Propynoic acid-(4'-chloro-3-fluorobiphenyl-4-yl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propiolic Acid | HCID 10110 | — |
| Reactant | 4'-Chloro-3-fluoro[1,1'-biphenyl]-4-amine | HCID 20099618 | — |
| Solvent | Cyclohexane ethylacetate | HCID 21867204 | — |
| Product | Propynoic acid-(4'-chloro-3-fluorobiphenyl-4-yl)amide | HCID 86060760 | — |
Reaction Steps
Prepared analogously to Example 1.1.b. from 4′-chloro-3-fluorobiphenyl-4-ylamine and propynoic acid. Yield: 0.16 g (43.7% of theory); C15H9ClFNO (M=273.69); calc.: molecular ion peak (M+H)+: 274/276; found: molecular ion peak (M+H)+: 274/276; Rf value: 0.3 (silica gel, cyclohexane/ethyl acetate (3:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-c2048dbe93a74a6caf66a26b1f236256 |
| Source note | uspto-grants-2009_09 |