HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Iodobenzyl alcohol → 3-(4-Hydroxymethylphenyl)propynoic acid-(4'-chlorobiphenyl-4-yl)methylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Iodobenzyl alcohol | HCID 29012 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | Propynoic acid-(4'-chlorobiphenyl-4-yl)methylamide | HCID 86047930 | — |
| Product | 3-(4-Hydroxymethylphenyl)propynoic acid-(4'-chlorobiphenyl-4-yl)methylamide | HCID 68819597 | — |
Reaction Steps
Prepared analogously to Example 1.2.a. from 4-iodobenzyl alcohol and propynoic acid-(4′-chlorobiphenyl-4-yl)methylamide. Yield: 0.52 g (90% of theory); C23H18ClNO2 (M=375.85); calc.: molecular ion peak (M+H)+: 376/378; found: molecular ion peak (M+H)+: 376/378; Rf value: 0.4 (silica gel, dichloromethane/methanol/ammonia (10:1:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-53c4889e70674dea8a0c2cd8450c4ea6 |
| Source note | uspto-grants-2009_09 |