HCID 58877792, compound → HCID 57845773, compound

HRID 735010Notes

Reaction equation

HRID 735010 reaction equation
I[C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([CH3:13])[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[Cl:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]2[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:33])[C:31]#[CH:32])=[CH:25][CH:24]=2)=[CH:19][CH:18]=1>ClCCl.CO>[Cl:16][C:17]1[CH:18]=[CH:19][C:20]([C:23]2[CH:28]=[CH:27][C:26]([NH:29][C:30](=[O:33])[C:31]#[C:32][C:2]3[CH:15]=[CH:14][C:5]([CH2:6][N:7]4[CH2:12][CH2:11][CH:10]([CH3:13])[CH2:9][CH2:8]4)=[CH:4][CH:3]=3)=[CH:25][CH:24]=2)=[CH:21][CH:22]=1

Participants

4

Reactant 2

HCID 58877792HCID 58877792, compoundHCID 86060771Propynoic acid-(4'-chlorobiphenyl-4-yl)amide

Product 1

HCID 57845773HCID 57845773, compound

Reagents, catalysts & solvents 1

HCID 21226129Dichloromethane methanolSolvent

Procedure

Prepared analogously to Example 1.1.d. from 1-(4-iodobenzyl)4-methylpiperidine and propynoic acid-(4′-chlorobiphenyl-4-yl)amide. Yield: 50 mg (27% of theory); C28H27ClN2O (M=442.99); calc.: molecular ion peak (M+H)+: 443/445; found: molecular ion peak (M+H)+: 443/445; Rf value: 0.45 (silica gel, dichloromethane/methanol (10:1)).

Workup

  1. customPrepared analogously to Example 1.1.d

Sources & evidence

ORD record
ord-c180f36b45c44ab2aeb2a856d095856d
Source dataset
uspto-grants-2009_09
Patent number
US07592373B2

Reaction notes

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