HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 68816798, compound → HCID 57845815, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 68816798 | HCID 68816798 | — |
| Reactant | Propynoic acid-(4'-chlorobiphenyl-4-yl)amide | HCID 86060771 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 57845815 | HCID 57845815 | — |
Reaction Steps
Prepared analogously to Example 1.1.d. from 1-(4-iodobenzyl)-4-methylpiperidin-4-ol and propynoic acid-(4′-chlorobiphenyl-4-yl)amide. Yield: 25 mg (13% of theory); melting point: 192° C.-193° C.; C28H27ClN2O2 (M=458.99); calc.: molecular ion peak (M+H)+: 459/461; found: molecular ion peak (M+H)+: 459/461; Rf value: 0.2 (silica gel, dichloromethane/methanol (10:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-3f500d4d3b2e45cca76633cc4a674dea |
| Source note | uspto-grants-2009_09 |