HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Iodophenethyl)pyrrolidine → 3-[4-(2-Pyrrolidin-1-ylethyl)phenyl]propynoic acid-(4'-chlorobiphenyl-4-yl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Iodophenethyl)pyrrolidine | HCID 68815836 | — |
| Reactant | Propynoic acid-(4'-chlorobiphenyl-4-yl)amide | HCID 86060771 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-[4-(2-Pyrrolidin-1-ylethyl)phenyl]propynoic acid-(4'-chlorobiphenyl-4-yl)amide | HCID 57845790 | — |
Reaction Steps
Prepared analogously to Example 2.1.e. from propynoic acid-(4′-chlorobiphenyl-4-yl)amide and 1-[2-(4-iodophenyl)ethyl]pyrrolidine. Yield: 70 mg (32.8% of theory); melting point: 217-218 C; C27H25ClN2O (M=428.96); calc.: molecular ion peak (M+H)+: 429/431; found: molecular ion peak (M+H)+: 429/431; Rf value: 0.3 (silica gel, dichloromethane/methanol (10:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-275f04bc74b741d6b1da0afa9367f83a |
| Source note | uspto-grants-2009_09 |