HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(4-Iodophenethyl)pyrrolidine → 3-[4-(2-Pyrrolidin-1-ylethyl)phenyl]propynoic acid-(4-prop-1-ynylphenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(4-Iodophenethyl)pyrrolidine | HCID 68815836 | — |
| Reactant | Propynoic acid-(4-prop-1-ynylphenyl)amide | HCID 86060737 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-[4-(2-Pyrrolidin-1-ylethyl)phenyl]propynoic acid-(4-prop-1-ynylphenyl)amide | HCID 57845753 | — |
Reaction Steps
Prepared analogously to Example 2.1.e. from propynoic acid-(4-prop-1-ynylphenyl)amide and 1-[2-(4-iodophenyl)ethyl]pyrrolidine. Yield: 20 mg (11% of theory); melting point: 198° C.-199° C.; C24H24N2O (M=356.47); Rf value: 0.1 (silica gel, dichloromethane/methanol (10:1))
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-aadc41fb2d6c44f58defe4738fd0823d |
| Source note | uspto-grants-2009_09 |