HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(2,6-Dimethyl-piperidin-1-ylmethyl)-phenylamine → 3-(4'-Chlorobiphenyl-4-yl)propynoic acid-[4-(2,6-dimethylpiperidin-1-ylmethyl)phenyl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(2,6-Dimethyl-piperidin-1-ylmethyl)-phenylamine | HCID 3153997 | — |
| Reactant | (4'-Chlorobiphenyl-4-yl)propynoic acid | HCID 68816492 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(4'-Chlorobiphenyl-4-yl)propynoic acid-[4-(2,6-dimethylpiperidin-1-ylmethyl)phenyl]amide | HCID 57845738 | — |
Reaction Steps
Prepared analogously to Example 3.8. from (4′-chlorobiphenyl-4-yl)propynoic acid and 4-(2,6-dimethylpiperidin-1-ylmethyl)phenylamine. Yield: 100 mg (22% of theory); melting point: 158° C.-163° C.; C29H29ClN2O (M=457.01); calc.: molecular ion peak (M+H)+: 458/460 (Cl); found: molecular ion peak (M+H)+: 458/460 (Cl); Rf value: 0.50 (silica gel, dichloromethane/methanolic ammonia (90:10:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-97362844f1464d7abdb90a9b7aba13bc |
| Source note | uspto-grants-2009_09 |