HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[(Cyclohexylmethylamino)methyl]phenylamine hydrochloride → 3-(4'-Chlorobiphenyl-4-yl)propynoic acid-{4-[(cyclohexylmethylamino)methyl]phenyl}amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[(Cyclohexylmethylamino)methyl]phenylamine hydrochloride | HCID 68816147 | — |
| Reactant | (4'-Chlorobiphenyl-4-yl)propynoic acid | HCID 68816492 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(4'-Chlorobiphenyl-4-yl)propynoic acid-{4-[(cyclohexylmethylamino)methyl]phenyl}amide | HCID 68816743 | — |
Reaction Steps
Prepared analogously to Example 3.8. from (4′-chlorobiphenyl-4-yl)propynoic acid and 4-[(cyclohexylmethylamino)methyl]phenylamine hydrochloride. Yield: 60 mg (13% of theory); melting point: 205° C.-210° C.; C29H29ClN2O (M=457.01); calc.: molecular ion peak (M+H)+: 457/459 (Cl); found: molecular ion peak (M+H)+: 457/459 (Cl); Rf value: 0.60 (silica gel, dichloromethane/methanol (90:10)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-935ca1e300454c03bc776431e9201680 |
| Source note | uspto-grants-2009_09 |