HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia methanol dichloromethane → 3-(4'-Chlorobiphenyl-4-yl)propynoic acid-(4-{[(2-methoxyethyl)methylamino]methyl}phenyl)amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | 4-{[(2-Methoxyethyl)methylamino]methyl}phenylamine | HCID 23507461 | — |
| Reactant | (4'-Chlorobiphenyl-4-yl)propynoic acid | HCID 68816492 | — |
| Product | 3-(4'-Chlorobiphenyl-4-yl)propynoic acid-(4-{[(2-methoxyethyl)methylamino]methyl}phenyl)amide | HCID 57845849 | — |
Reaction Steps
Prepared analogously to Example 3.8. from (4′-chlorobiphenyl-4-yl)propynoic acid and 4-{[(2-methoxyethyl)methylamino]methyl}phenylamine. Yield: 150 mg (35% of theory); melting point: 130° C.-133° C.; C26H25ClN2O2 (M=432.94); calc.: molecular ion peak (M+H)+: 433/435 (Cl); found: molecular ion peak (M+H)+: 433/435 (Cl); Rf value: 0.50 (silica gel, dichloromethane/methanol/ammonia (90:10:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-56570c018f9c44539a62c10518429cf7 |
| Source note | uspto-grants-2009_09 |