HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-(4'-Chlorobiphenyl-4-yl)propynoic acid-[3-chloro-4-(2-dimethylaminoethoxy)phenyl]amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | 3-Chloro-4-(2-diethylaminoethoxy)phenylamine | HCID 16791676 | — |
| Reactant | (4'-Chlorobiphenyl-4-yl)propynoic acid | HCID 68816492 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 3-(4'-Chlorobiphenyl-4-yl)propynoic acid-[3-chloro-4-(2-dimethylaminoethoxy)phenyl]amide hydrochloride | HCID 68816772 | — |
Reaction Steps
Prepared analogously to Example 3.7.c. from (4′-chlorobiphenyl-4-yl)propynoic acid and 3-chloro-4-(2-diethylaminoethoxy)phenylamine. Yield: 0.28 g (58% of theory); melting point: 226° C.-233° C.; C27H26Cl2N2O2 (M=481.41)*HCl; calc.: molecular ion peak (M+H)+: 481/3/5 (Cl2); found: molecular ion peak (M+H)+: 481/3/5 (Cl2); Rf value: 0.45 (silica gel, dichloromethane/methanol (90:10)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-361bfbbd443c479e9c122bdfae2f7ce2 |
| Source note | uspto-grants-2009_09 |