HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Tert-butyl-(3-chlorobiphenyl-4-ylethynyl)dimethylsilane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (tert-Butyldimethylsilyl)acetylene | HCID 2757281 | — |
| Reactant | 3-Chlorobiphenyl-4-yl trifluoromethanesulfonate | HCID 18001079 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Catalyst | Dichlorobis(triphenylphosphine)palladium | HCID 6102075 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Tert-butyl-(3-chlorobiphenyl-4-ylethynyl)dimethylsilane | HCID 68816298 | — |
Reaction Steps
0.84 g (1.2 mmol) of bis-(triphenylphosphine)palladium (II) chloride, 0.23 g (1.2 mmol) of copper (I) iodide, and 6.28 mL (33.6 mmol) of (tert-butyldimethylsilyl)acetylene is added under an argon atmosphere to a solution of 8.1 g (24 mmol) of 3-chlorobiphenyl-4-yl trifluoromethanesulfonate in 50 mL of absolute DMF and 13.31 mL (96 mmol) of triethylamine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-ef609e1871c64a76a13ef6d6e918cd23 |
| Source note | uspto-grants-2009_09 |