HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorine → 3-(3-chlorobiphenyl-4-yl)propynoic acid-[3-chloro-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorine | HCID 24526 | — |
| Reactant | 3-Chloro-4-(2-diethylaminoethoxy)phenylamine | HCID 16791676 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | (3-chlorobiphenyl-4-yl)propynoic Acid | HCID 68818528 | — |
| Product | 3-(3-chlorobiphenyl-4-yl)propynoic acid-[3-chloro-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride | HCID 68819706 | — |
Reaction Steps
Prepared analogously to Example 3.8.a. from (3-chlorobiphenyl-4-yl)propynoic acid and 3-chloro-4-(2-diethylaminoethoxy)phenylamine. Yield: 0.35 g (68% of theory); melting point: 195° C.-200° C.; C27H26Cl2N2O2*HCl (M=517.87); calc.: molecular ion peak (M+H)+: 481/3/5 (Cl2); found: molecular ion peak (M+H)+: 481/3/5 (Cl2); Rf value: 0.6 (silica gel, dichloromethane/methanol/ammonia (90:10:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-14406dc6e994401ca26b0297db46b45b |
| Source note | uspto-grants-2009_09 |