4-(2-Diethylaminopropoxy)phenylamine → 3-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-[4-(2-diethylaminopropoxy)phenyl]amide

Participants

Reaction Steps

Prepared analogously to Example 2.3.f. from 67 mg (0.3 mmol) of 4-(2-diethylaminopropoxy)phenylamine and 75 mg (0.3 mmol) of (2-chloro-4-trifluoromethylphenyl)propynoic acid. Yield: 71 mg (52% of theory); melting point: 172° C.-176° C.; C23H24ClF3N2O2 (M=452.90); calc.: molecular ion peak (M+H)+: 453/455; found: molecular ion peak (M+H)+: 453/455; Rf value: 0.30 (silica gel, dichloromethane/methanol (9:1)).

Provenance & Evidence