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{4-[2-(Diethylamino)ethoxy]phenyl}methanamine → 3-(2-Chloro-4-methylphenyl)propynoic acid-[4-(2-diethylaminoethoxy)phenyl]methylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | {4-[2-(Diethylamino)ethoxy]phenyl}methanamine | HCID 235944 | — |
| 反応物 | (2-Chloro-4-trifluoromethylphenyl)propynoic acid | HCID 68817422 | — |
| 溶媒 | Dichloromethane methanol | HCID 21226129 | — |
| 生成物 | 3-(2-Chloro-4-methylphenyl)propynoic acid-[4-(2-diethylaminoethoxy)phenyl]methylamide | HCID 68816196 | — |
反応手順
Prepared analogously to Example 2.3.f. from [4-(2-diethylaminoethoxy)phenyl]methylamine and (2-chloro-4-trifluoromethylphenyl)propynoic acid. Yield: 60 mg (22% of theory); melting point: 135° C.-138° C.; C23H24ClF3N2O2 (M=452.90); calc.: molecular ion peak (M+H)+: 453/455; found: molecular ion peak (M+H)+: 453/455; Rf value: 0.4 (silica gel, dichloromethane/methanol (9:1)).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07592373B2 |
| 出典データセット | uspto-grants-2009_09 |
| ORD ID | ord-00ab607748f4433d9ace12dca0689b73 |
| 出典メモ | uspto-grants-2009_09 |