HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-(2-diethylaminoethoxy)phenylamine → 3-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-[3-chloro-4-(2-diethylaminoethoxy)phenyl]amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-(2-diethylaminoethoxy)phenylamine | HCID 16791676 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | (2-Chloro-4-trifluoromethylphenyl)propynoic acid chloride | HCID 86060673 | — |
| Product | 3-(2-Chloro-4-trifluoromethylphenyl)propynoic acid-[3-chloro-4-(2-diethylaminoethoxy)phenyl]amide | HCID 57845775 | — |
Reaction Steps
Prepared analogously to Example 4.1.d. from (2-chloro-4-trifluoromethylphenyl)propynoic acid chloride and [2-(2-chloro-4-aminophenoxy)ethyl]diethylamine. Yield: 0.26 g (27.5% of theory); C22H21Cl2F3N2O2 (M=473.32); calc.: molecular ion peak (M+H)+: 473/475; found: molecular ion peak (M+H)+: 473/475; Rf value: 0.5 (silica gel, dichloromethane/methanol/ammonia (9:1:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-6d4721fdf7c24690a5dd6a5249ed452c |
| Source note | uspto-grants-2009_09 |