HuagongsheHuagongshe Chemistry Print Report · For research reference only
DCM MeOH AcOH → 3-([1,1'-Biphenyl]-4-YL)propiolic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | DCM MeOH AcOH | HCID 21877243 | — |
| Reactant | 3-Biphenyl-4-yl-2,3-dibromopropanecarboxylic acid | HCID 68816027 | — |
| Product | 3-([1,1'-Biphenyl]-4-YL)propiolic acid | HCID 65454184 | — |
Reaction Steps
Prepared analogously to Example 3.4.b. from 3-biphenyl-4-yl-2,3-dibromopropanecarboxylic acid. Yield: 2.8 g (96.8% of theory); C15H10O2 (M=222.24); melting point: 170° C.; calc.: molecular ion peak (M+H)+: 223; found: molecular ion peak (M+H)+: 223; Rf value: 0.4 (silica gel, dichloromethane/methanol/acetic acid (90:10:1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-2e8bb6f47a574f6cb64b5174bfc4edde |
| Source note | uspto-grants-2009_09 |