HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Chloro-4-(2-diethylaminoethoxy)phenylamine → 3-(2,4,6-trichlorophenyl)propynoic acid-[3-chloro-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Chloro-4-(2-diethylaminoethoxy)phenylamine | HCID 16791676 | — |
| Reactant | Ammonia methanol dichloromethane | HCID 21584172 | — |
| Reactant | (2,4,6-trichlorophenyl)propynoic Acid | HCID 68816017 | — |
| Product | 3-(2,4,6-trichlorophenyl)propynoic acid-[3-chloro-4-(2-diethylaminoethoxy)phenyl]amide Hydrochloride | HCID 68819275 | — |
Reaction Steps
Prepared analogously to Example 2.3.f. from (2,4,6-trichlorophenyl)propynoic acid and [2-(2-chloro-4-aminophenoxy)ethyl]diethylamine. Yield: 0.72 g (82.9% of theory); melting point: 188° C.-191° C.; C21H20Cl4N2O2*HCl (M=510.67); calc.: molecular ion peak (M+H)+: 473/475/477/479/481; found: molecular ion peak (M+H)+: 473/475/477/479/481; Rf value: 0.4 (silica gel, dichloromethane/methanol/ammonia (90:10:0.1)).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07592373B2 |
| Source dataset | uspto-grants-2009_09 |
| ORD ID | ord-346d59803c284c358c7e42e58c94db68 |
| Source note | uspto-grants-2009_09 |